Alloxaninduced diabetes, a common model for evaluating. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Alloxan or mesoxalylurea is an organic compound based on a pyrimidine heterocyclic skeleton. Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the.
Cytotoxic compound that causes oxidative base damage to nuclear dnaalloxan monohydrate is used as a precursor to prepare purple dye murexide. There is no warranty of accuracy or completeness of. Alloxan monohydrate induces diabetes in animals, although streptozotocin. The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas t.
By using a single intraperitoneal dose of 120 mgkg of alloxan monohydrate dissolved in cold saline solution administered rapidly and prevented from direct sunlight so as to prevent degradation of. Alloxan which is chemically known as 5,5dihydroxyl pyrimidine2,4,6trione is an organic compound, a urea derivative, a carcinogen and cytotoxic glucose analog. Further, it is a strong oxidizing agent and it forms a hemiacetal with its reduced reaction product dialuric acid. The mechanisms of alloxan and streptozotocininduced diabetes. Pdf the extracts of berberis lycium and diabetes mellitus in. Alloxan c4h2n2o4 cid 5781 structure, chemical names, physical and. Alloxan is one of the common diabetogenic agents often used to assess the antidiabetic potential of both pure compounds and plant.
Pdf dose optimization of alloxan for diabetes in albino mice. After an overnight fast, the rats were injected single dose 125mgkg of freshly prepared 5% solution of alloxan monohydrate in 0. The rats were injected with alloxan monohydrate in saline 0. Alloxan diabetes definition of alloxan diabetes by.
The other diabetogenic chemical is less toxic but comparatively expensive. Orthorhombic crystals from anhydrous acetone or glacial acetic acid or by sublimation in vacuo. The induction of diabetes was confirmed after the 5th day of alloxan treatment by. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. This compound has a high affinity for water and therefore exists as the monohydrate. Administration of alloxan to diabetic control group significantly increased the blood glucose level. Protein glycation, the most important source of free radicals, is leaded. The compound has the molecular formulae, c 4 h 2 n 2 o 4 and a relative molecular mass of 142. The extracts of berberis lycium and diabetes mellitus in alloxan monohydrate induced diabetic rats. Briefly overnight starved mice were made diabetic with a freshly prepared dose of alloxan monohydrate in pyrogen free water. Alloxaninduced diabetes, a common model for evaluating the. Pdf incidence of type ii diabetes is rapidly increasing worldwide. Pdf alloxaninduced diabetes, a common model for evaluating the.
Diabetes induction was done by single intra peritoneal injection of alloxan monohydrate 150 mgkg in saline. Sigmaaldrich offers a number of alloxan monohydrate products. Please take a look at the following rg link and pdf attachment. Fbg in alloxan induced diabetic rats in a doserelated fashion, and also, showed signif. It is also used in research models to induce diabetes and destroy beta cells.
Join researchers using high quality alloxan monohydrate. Research article alloxan induced diabetes mellitus in. The hyperglycemia was confirmed after 72 hrs by the. Antidiabetic activity of aqueous extract of cinnamomum. Szkudelski department of animal physiology and biochemistry, university of agriculture, poznan, poland received november 2, 2000 accepted march 20, 2001 summary alloxan and streptozotocin are widely used to induce experimental diabetes in animals.